These questions must be vetted before designing any enterprise-grade solutions using Power Platform
What is the organization's level of attraction to Microsoft technology in general?
Is the organization prepared to take a cloud solution?
Does the organization require the cloud solution to reside in a certain geographical region or country?
What kind of authentication ecosystem is established? Is it Microsoft's active directory or something different?
What are the IT security policies? Does the organization allow mobile workers?
What are the data protection policies?
Would the organization possibly require a data protection solution that cannot be implemented using a public cloud approach?
Is there any approved and followed cloud integration strategy?
What kind of legacy systems are operated in the organization? Do they offer any kind of API?
Is the organization using existing middleware for enterprise application integration? Is this solution compatible with Microsoft technology?
How consistent are the business processes across the organization? Are there major deviations in different regions? Is the organization able to consolidate business processes?
How many different languages should the solution support? Is the organization prepared to translate the terminology of the Dynamics 365 apps and their extensions into all required languages?
What is the planned user distribution across the globe? Are there any business and non-business hours? What times might be more suitable for running batch jobs?
What is the level of maturity of the organization's adoption and change management? Are they able to ensure smooth adoption of a major new IT solution?
All of these questions and certainly many more will impact how a Power Platform solution could be implemented, what are the areas with possibly increased efforts, and what are the major project risks and how to mitigate them.
Happy learning..